Views: 12 Author: MYCOMEDICINE Publish Time: 2024-03-06 Origin: 菌物药工程技术研究中心
Chemotherapy-induced alopecia (CIA) is one of the most common adverse reactions of chemotherapy. Clinical data shows that about 90% of patients will suffer from hair loss due to chemotherapy. Hair loss usually occurs in the first 2 weeks after starting to receive chemotherapy, and sometimes It becomes most severe in 1-2 months. Although most medical staff believe that hair loss is an inevitable side effect of chemotherapy and pay little attention to it, this symptom can lead to a decrease in patients' quality of life, treatment confidence and compliance, and a loss of self-esteem, and even affects about 8% to 13% of patients. Patients refuse chemotherapy because they find it difficult to accept the appearance changes caused by hair loss. Therefore, being able to reduce the adverse reaction of hair loss caused by chemotherapy is undoubtedly very meaningful to the patient himself.
So, why does chemotherapy cause hair loss? We all know that chemotherapy is a double-edged sword. While killing tumor cells, it can also cause damage to the body's normal proliferating tissue cells, including hair follicle cells. Chemotherapy drugs act on hair follicle cells and hair bulbs in the skin. cells, causing hair loss. There are also studies showing that allergic reactions to chemotherapy drugs in some patients can also cause hair loss. In addition, multi-drug combination chemotherapy, increased chemotherapy cycles, and long administration times will significantly increase the probability of hair loss.
In terms of alleviating the adverse reactions of hair loss caused by chemotherapy, clinical application studies have shown that bacterial drug polysaccharide preparations have a significant improvement effect.
A study by Li Ping, Jiang Chaohui and others from the 117th Hospital of the People's Liberation Army in Hangzhou reported that when gastric cancer patients were combined with lentinan preparations during chemotherapy, the adverse reactions on the skin and hair of the patients were significantly reduced compared with the control group.
Wang Yuehui and others reported that when patients with advanced colorectal cancer were combined with Ganoderma lucidum preparations during chemotherapy, the adverse reactions of hair loss were also significantly reduced.
Although mycopolysaccharide preparations combined with chemotherapy can significantly improve the symptoms of hair loss, many people may not understand which substance in the biomedicine plays a key role? How does this substance work?
According to scientific researchers from the Heilongjiang Provincial Fungal Drug Engineering Technology Research Center, among the fungal drug BRM biological response modifiers, there is a glucan with a structure of β-1,3-D, which not only has extremely high immune regulation and Anti-tumor activity, and has been confirmed to have biological activities of hair growth, hair fixation and hair loss prevention, such as Lentinus edodes β-glucan, Grifola frondosa β-glucan, Schizophyllum β-glucan, etc. Experiments have shown that β-glucan can significantly promote the entry of resting hair follicles into the growth phase and keep them in the growth phase for a long time, thereby reducing hair loss and promoting hair regeneration and growth.
In 2004, Zhejiang Fangge Pharmaceutical Co., Ltd. developed and launched China first nationally approved auxiliary anti-tumor product with Grifola Grifola polysaccharide as the main raw material - Grifola Grifola Capsules.
Approval number: National Drug Approval No. B20020023
Functions and Indications: Replenishing qi and strengthening the spleen. It is suitable for physical fatigue, mental fatigue, laziness, reduced diet, and abdominal distension after eating caused by spleen deficiency. It can also be used for tumor patients with the above-mentioned spleen deficiency syndrome.
