Views: 13 Author: Site Editor Publish Time: 2023-09-01 Origin: 菌物健康
The aroma of Antrodia camphorata is hard and flat. It has the effects of dispelling wind and promoting qi, removing stasis and promoting blood circulation, warming the middle and eliminating stagnation, detoxifying and reducing swelling, sedating and relieving pain, antibacterial, antiviral, antitumor, and improving the body's immunity; for the treatment of gastrointestinal pain, diarrhea and vomiting, food poisoning, poisonous mushrooms Poisoning, diabetes, alcoholic liver, fatty liver, liver cirrhosis, liver cancer, etc. have unique functions. Antrodia Antrodia has many physiologically active components, such as polysaccharides, triterpenoids, superoxide dismutase, adenosine, proteins (including immune proteins), vitamins, trace elements, nucleic acids, lectins, amino acids, sterols, fibers Factors, blood pressure stabilizing substances, etc.
Hepatitis B virus (HBV), reactive free radical oxidation, ethanol, carbon tetrachloride, and Propionibacterium acnes are important causes of liver disease [1]. Antrodia Cinnamomea can scavenge free radicals, enhance the activity of antioxidant enzymes, induce liver cell regeneration, and play a liver-protective role.
Studies have found that the polysaccharide (50μg/mL) of Antrodia camphorata strain B86 has no cytotoxicity, but has high anti-hepatitis B virus activity, and the effect is better than 1000U/mL α-interferon [2]; Both surface antigen (HBsAg) and hepatitis B E antigen (HBeAg) wild-type HBV have resistance activity, indicating that Antrodia camphorata has anti-HBV activity [3].
Research data shows that Antrodia antrodia is an effective direct scavenger of free radicals, and its extract (IC50=3.1mg/mL) can scavenge DPPH, hydroxyl and superoxide anion free radicals, inhibit lipid peroxidation, and reduce low-density lipoprotein Oxidation modification activity, reduce the chelation and reduction ability of iron ions, and the ability to resist γ-ray (20kgy) radiation oxidation [4]. Treating mice with acute alcohol poisoning with Antrodia camphorata, the contents of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase and bilirubin were significantly reduced, and the effect was equivalent to that of silymarin, indicating that Antrodia camphorata can prevent alcohol-induced liver injury[ 5].
Carbon tetrachloride will release carbon trichloride free radicals under normal conditions, interfere with the structure and function of macromolecular substances such as fat and protein on the cell membrane, and cause liver poisoning and liver fibrosis. In carbon-treated mice, the expression levels of collagen 1, transforming growth factor-β1 (TGF-β1), and TIMP-1 were down-regulated, and the ratio of total glutathione/oxidized glutathione (GSH/GSSG) was increased. The activities of glutathione peroxidase, glutathione reductase, and glutathione-S transferase were significantly reduced, neutrophil infiltration, edema, necrosis and other symptoms caused by carbon tetrachloride were rare, and microfibrosis The nodules disappeared, and the liver fibrosis gradually reversed [6], indicating that Antrodia Cinnamomea can treat liver damage and liver fibrosis caused by carbon tetrachloride.
Treating mice with Propionibacterium acnes + lipopolysaccharide will induce acute hepatitis, and after taking Cinnamomum camphora polysaccharide ACN2a [0.4-0.8g/(kg d)], the activities of AST and ALT in the serum are significantly reduced, indicating that Antrodia camphorata can treat Acute hepatitis induced by Propionibacterium acnes + lipopolysaccharide [7].
2,2',5,5'-tetramethoxy-3,4,3',4'-dimethyllenedioxy-6,6'-dimethyl biphenyl has resistance activity to wild-type and mutant hepatitis B virus, and biphenyl has The resistance of wild-type HBV cell ES2 is equivalent to 1000 U/mL α-2a interferon, and the resistance to mutant HBV cell M33 is equivalent to 250 U/mL α-2a interferon[8].
Recently, Camphorataimide B was isolated from Antrodia cinnamomea. At a dose of 50 μmol/L, the inhibition efficiency of the substance on the expression of hepatitis B surface antigen (HBsAg) and hepatitis B E antigen (HBeAg) was 35.2% and 12.8%, respectively. Cyclohexenone Antroquinonol in the mycelia and fruiting bodies of Antrodia camphorata has the function of inhibiting the synthesis of HBsAg and HBeAg, and thus has the function of inhibiting HBV [3].
References:
[1]姜喜梅,孙建光.肝病中医外治法临床应用综述[J].山东中医杂志, 2015(4):3.DOI:CNKI:SUN:SDZY.0.2015-04-042.
[2]Lee I H , Huang R L , Chen C T ,et al.Antrodia camphorata polysaccharides exhibit anti-hepatitis B virus effects[J].FEMS Microbiology Letters, 2002.DOI:10.1111/j.1574-6968.2002.tb11110.x.
[3]Shen C C , Yang H C , Huang R L ,et al.Anti-HBV principle from the culture broth of Antrodia camphorata (strain # CCRC-35396)[J].中医药杂志, 2005.
[4]George,Hsiao,Ming-Yi,et al.Antioxidative and Hepatoprotective Effects of Antrodia camphorata Extract[J].Journal of Agricultural & Food Chemistry, 2003.DOI:10.1021/jf021159t.
[5]Lu Z M , Tao W Y , Zou X L ,et al.Protective effects of mycelia of Antrodia camphorata and Armillariella tabescens in submerged culture against ethanol-induced hepatic toxicity in rats[J].Journal of Ethnopharmacology, 2007, 110(1):160-164.DOI:10.1016/j.jep.2006.09.029.
[6]Tsai M C , Song T Y , Shih P H ,et al.Antioxidant properties of water-soluble polysaccharides from Antrodia cinnamomea in submerged culture[J].Food Chemistry, 2007, 104(3):1115-1122.DOI:10.1016/j.foodchem.2007.01.018.
[7]Han H F , Nakamura N , Zuo F ,et al.Protective Effects of a Neutral Polysaccharide Isolated from the Mycelium of Antrodia cinnamomea on Propionibacterium acnes and Lipopolysaccharide Induced Hepatic Injury in Mice[J].Chemical & Pharmaceutical Bulletin, 2006, 54(4):496-500.DOI:10.1248/cpb.54.496.
[8]黄瑞龄(Ray-Ling Huang),黄奎岚(Quillan Huang),陈介甫(Chieh-Fu Chen),et al.Anti-Viral Effects of Active Compounds from Antrodia camphorata on Wild-Type and Lamivudine-Resistant Mutant HBV[J].The Chinese Pharmaceutical Journal, 2003, 55(5):371-379.
