Views: 1 Author: 菌物健康 Publish Time: 2023-03-08 Origin: [1] Huang Xiaowen, Yu Zhongming, Dong Yu, et al. Application records of Sanghuang in ancient Chinese classics and its modern medicinal research progress [J]. Chinese Journal of Traditional Chinese Med
Phellinus is a fungal parasite on mulberry trees, also known as parasites on mulberry trees, mulberry ears, mulberry trees, etc. in ancient books. As a traditional Chinese medicine, it has a long history of application. It has the functions of promoting blood circulation, removing blood stasis, relieving pain, clearing heat and detoxifying, tonifying, astringent and astringent.
Studies have found that Phellinus has anti-tumor, anti-metastasis, immune regulation, and anti-oxidation effects. Based on the current various preparation processes, technicians at this stage have extracted a variety of effective active ingredients from Phellinus Phellinus, including polysaccharides, polyphenols, flavonoids, terpenoids, steroids, etc., suggesting that Phellinus Phellinus has a positive effect on the prevention and treatment of tumors .
Cell proliferation is an important feature for living organisms to survive and develop. Normal cell proliferation can resist aging, bring out the old and bring forth the new, and maintain the growth and vitality of the body, while tumor cell proliferation can go too far, which can cause cell growth out of control and malignant proliferation to cause disease. Through the study of controlling the growth characteristics of malignant tumors and inhibiting the proliferation of tumor cells, Phellinus has been found to have the effect of inhibiting the growth of various cancer cells.
Inhibiting the proliferation and growth of tumor cells is the embodiment of Phellinus antitumor activity. Studies have shown that Phellinus can inhibit the activity of breast cancer MDA-MB-231 cells, and has inhibitory effects on the proliferation of many types of cancer. Phellinus can interfere with various tumor cells such as liver cancer cell HepG2, lung cancer cell A549, cervical cancer cell Hela, etc., and inhibit the proliferation of tumor cells to varying degrees, and in vivo experiments have found that Phellinus can inhibit the growth of sarcoma in rats.
Phellinus polysaccharide extract, Phellinus fruiting body polysaccharide extract, and Phellinus fermented broth polysaccharide extract can inhibit tumor proliferation in H22 tumor-bearing mice. Phellinus has inhibitory effects on tumor growth in H22, S180, and Lewis tumor-bearing mice, and can interfere with the proliferation of breast cancer MCF7 and ovarian cancer OVCA278 cells. Phellinus crude polysaccharide intervenes in tumor EC109 and SiHa cells, and has the effect of inhibiting tumor cell proliferation.
In addition, Phellinus polysaccharides have anti-tumor effects both in vivo and in vitro, and can up-regulate the tumor suppressor gene PTEN in S180 sarcoma mice, down-regulate the oncogene C-myc protein, and significantly inhibit cell proliferation in vitro. Phellinus has a direct inhibitory effect on HepG-2 cells. Phellinus has a direct inhibitory effect on HepG-2 cells and can block the S+G2 cycle, thereby inhibiting tumor proliferation.
