Views: 2 Author: 菌物健康 Publish Time: 2022-09-02 Origin: [1]赵慧慧, 卢伟东, 徐丽丽,等. 绣球菌多糖诱导K562、THP-1细胞凋亡的研究[J]. 中国农学通报, 2013, 000(021):149-153. [2] Naohito O , Mai F , Miura N N , et al. Antitumor β-Glucan from the Cultured Fruit Body of Agaricus blazei[J]. Bi
Hydrangea, Latin scientific name Sparassis crispa, is a non-triloporus, Hydrangea, Hydrangea genus. The fruiting body is medium to large, fleshy, with many branches from a sturdy stalk, and the ends of the branches form numerous tortuous petals, which are named after a huge hydrangea. Because of its super-high ability to activate immunity, it is known as "Dream Magic Mushroom" in Japan. Ordinary mushrooms grow on the shady side, while hydrangea mushrooms need more than 10 hours of irradiation every day, so they are also called "sunshine mushrooms".
Antitumor
Many studies have confirmed that Embroidery has good antitumor activity. Hydrangea polysaccharide can significantly inhibit the proliferation of human leukemia cells K562 and THP-1 cultured in vitro and induce their apoptosis; sarcoma-bearing S-180 mice were fed with Hydrangea powder for 5 weeks and found that their sarcoma was significantly smaller than that of the control group, and their lives were prolonged. , Ohno et al. also reported that the polysaccharide components isolated from Embroidery had antitumor activity for sarcoma-bearing S-180 mice, and oral administration of Embroidered polysaccharides to mice could inhibit angiogenesis and metastasis. An oral trial of 14 patients with tumors volunteered to take Hydrangea sp. improved in 9 patients. Studies have shown that the anti-tumor activity of Embroidery is mainly due to its β-glucan (SCG), and SCG mainly fights tumors by stimulating the production of cytokines.
Immunomodulatory
Oral administration of Emidiococcus can activate Th1 cells and inhibit Th2 cell activity, thereby promoting the Th1/Th2 balance to a Th1-dominated immune switch. Embroidered β-glucan can activate dendritic cells through the MAPK and NF-κB signaling pathways downstream of the Toll-like membrane receptor (TLR4), indicating that Embroidery can increase the efficiency of dendritic cell-based cancer immunotherapy. Harada et al. showed that in DBA/2 mouse spleen cells, Embroidered β-glucan can induce the production of γ-interferon and interleukin-12 p70. Intraperitoneal injection or oral administration of Emidiococcus polysaccharide in mice has a significant recovery effect on leukopenia caused by cyclophosphamide, and β-glucan promotes the synthesis of interleukin-8 in a dose-dependent manner to increase related immune functions, and can up-regulate The production of inducible nitric oxide synthase (iNOS) in macrophages to increase NO production may be mediated by mitogen-activated protein kinase MAPK to induce NO release, so Embroidery is expected to be used to enhance cancer patients, the elderly and the immunocompromised Immune function in children.
Anti-inflammatory
Aqueous extract of Embroidered Coccus (WESC) can inhibit compound 48/80-induced systemic allergic reaction and serum histamine release in mice, and reduce immunoglobulin E (IgE)-mediated passive skin allergic reaction. Furthermore, WESC reduced histamine release and pro-inflammatory cytokines, such as tumor necrosis factor TNF-α, IL-6 and TNF-α, activated by phorbol 12-myristate-13-acetate and calcium ionophore A23187 in human mast cells. The release of IL-1β was dependent on nuclear factor kappa B, extracellular signal-regulated protein kinase and p38 mitogen-activated protein kinase. The results suggest that WESC is expected to be used in the treatment of allergic inflammatory diseases.
