Views: 7 Author: 菌物健康 Publish Time: 2023-09-22 Origin: 菌物药工程技术研究中心
Data show that the incidence of digestive tract tumors in China accounts for 40% of all cancer incidences, and the mortality rate accounts for 50% of all cancer deaths. In 2020, 41.5% of all newly diagnosed cancer cases in China were digestive system cancers.
Digestive tract tumors usually do not cause obvious symptoms or pain, and the tumors grow slowly, so people fail to detect and treat them early. Once symptoms such as indigestion, abdominal pain, weight loss, etc. appear, it is usually at an advanced stage. By then, the tumor may have spread to other organs, which not only makes treatment more difficult, but the prognosis is often poor.
Hericium erinaceus plays a very important role in assisting the treatment and rehabilitation of digestive tract tumors. It can inhibit the synthesis of DNA and RNA in tumor cells, inhibit tumor growth and even kill tumor cells. It is a very effective A comprehensive and valuable drug with very significant effects, monkey mushroom tablets were successfully developed as early as 1977 and approved for clinical treatment of gastric cancer, esophageal cancer and other digestive tract cancers.
The active substance of Hericium erinaceus that has anti-tumor effect is Hericium erinaceus polysaccharide. Chen Guoliang’s research further reported: The anti-tumor effect of Hericium erinaceus is the β-glucan in the polysaccharide, which contains β-(1-3)-glucan. Glycan backbone and β-(1-6)-side chains.
The anti-tumor mechanism of Hericium polysaccharides is by increasing the phagocytic capacity of macrophages, promoting the formation of immunoglobulins, increasing white blood cells, increasing the lymphocyte transformation rate, and improving the body's own disease resistance or enhancing the body's response to radiotherapy and chemotherapy. Tolerance to achieve the purpose of inhibiting the growth and expansion of cancer cells.
Hericium erinaceus has a significant effect on inhibiting tumor growth. Nie Jisheng et al. reported that the inhibitory rate of Hericium erinaceus polysaccharide on S-180 sarcoma can reach 59.1%-66.5%, and it can significantly increase the weight of the thymus and spleen of tumor-bearing mice.
Zhou Hui et al. studied the experiment and experimental mechanism of Hericium erinaceus polysaccharide inhibiting Lewis lung cancer and found that Hericium erinaceus polysaccharide can cause a significant decrease in tumor necrosis factor-α and a significant increase in interleukin-2 in mice. Therefore, Hericium erinaceus polysaccharide can By regulating the balance of intracellular tumor necrosis factor-α and interleukin-2, it effectively inhibits the growth of tumor cells.
Hericium polysaccharide can help restore the immune function of tumor patients, shrink tumors, improve physical signs, and promote the recovery of tumor patients.
Research reports from Shanghai Xuhui District Central Hospital, Shanghai Yangpu District Central Hospital, Shanghai Cancer Hospital, etc.: 166 cases of advanced gastric cancer and esophageal cancer were treated with monkey mushroom tablets for 2 months. Results: Markedly effective (the mass shrank by more than 1/2, symptoms were significantly improved, pain was relieved, and appetite increased) 15.7%; effective (the mass shrank by less than 1/2, symptoms improved) 53.6%; the total effective rate was 69.3%.
Clinical studies have shown that the application of Hericium erinaceus polysaccharide in combination with radiotherapy and chemotherapy has an effective rate of 85.2% in treating tumors. The adverse reactions are significantly less severe than those of radiotherapy and chemotherapy alone. The patient's vomiting, fever, diarrhea, anorexia, dizziness, sleep and other adverse phenomena are also reduced. Significant improvement, which shows that Hericium polysaccharide combined with radiotherapy and chemotherapy can help most patients persist in radiotherapy and chemotherapy until the end of the course of treatment.
At present, scientific researchers' anti-tumor research on Hericium polysaccharides has involved research on active ingredients, mechanisms of action, and inhibition of cancer cell metastasis. A number of Hericium scientific research results are expected to be developed to help more people with tumors benefit. .
references:
[1] Ni Zongyao, Pan Xinhua, Bai Gao, Ni Feng. Fungal polysaccharides and tumors [M]. Shanghai: Shanghai Science and Technology Literature Press, 2016.
[2] Chen Ruoyun, Kang Jie. Chemistry of edible and medicinal fungi in China [M]. Shanghai: Shanghai Science and Technology Literature Press, 2016.
[3] Huang Niannian, Lin Zhibin, Chen Guoliang, et al. Chinese Food and Medicinal Mycology [M]. Shanghai: Shanghai Science and Technology Literature Press, 2016.
[4] Chen Hui, Qiang Xiaojun, Wu Weijie. Edible fungi and health [M]. Shanghai: Shanghai Science Popularization Press, 2021.
